| First Author | Michael-Titus A | Year | 1989 |
| Journal | Neuropharmacology | Volume | 28 |
| Issue | 2 | Pages | 117-22 |
| PubMed ID | 2716968 | Mgi Jnum | J:27905 |
| Mgi Id | MGI:75539 | Doi | 10.1016/0028-3908(89)90046-4 |
| Citation | Michael-Titus A, et al. (1989) Role of endogenous enkephalins in locomotion and nociception studied with peptidase inhibitors in two inbred strains of mice (C57BL/6J and DBA/2J). Neuropharmacology 28(2):117-22 |
| abstractText | Acetorphan, a parenterally active enkephalinase inhibitor, induced dose-dependently a naloxone-reversible analgesia on the hot-plate jump test in DBA/2J (DBA2) mice but was devoid of effects in C57BL/6J (C57) mice. By contrast, acetorphan increased locomotion in both strains; however, the DBA2 strain was much more sensitive than C57 mice to the locomotor stimulant effect. The increased locomotion was antagonized by naloxone in both strains. These data suggest that endogenous enkephalins modulate nociception and locomotion in the two inbred strains differently. |
