| First Author | Leushacke M | Year | 2013 |
| Journal | Cell Rep | Volume | 5 |
| Issue | 2 | Pages | 349-56 |
| PubMed ID | 24209744 | Mgi Jnum | J:205131 |
| Mgi Id | MGI:5544139 | Doi | 10.1016/j.celrep.2013.09.025 |
| Citation | Leushacke M, et al. (2013) Lgr5(+) gastric stem cells divide symmetrically to effect epithelial homeostasis in the pylorus. Cell Rep 5(2):349-56 |
| abstractText | The pyloric epithelium continuously self-renews throughout life, driven by limited reservoirs of resident Lgr5+ adult stem cells. Here, we characterize the population dynamics of these stem cells during epithelial homeostasis. Using a clonal fate-mapping strategy, we demonstrate that multiple Lgr5+ cells routinely contribute to epithelial renewal in the pyloric gland and, similar to what was previously observed in the intestine, a balanced homeostasis of the glandular epithelium and stem cell pools is predominantly achieved via neutral competition between symmetrically dividing Lgr5+ stem cells. Additionally, we document a lateral expansion of stem cell clones via gland fission under nondamage conditions. These findings represent a major advance in our basic understanding of tissue homeostasis in the stomach and form the foundation for identifying altered stem cell behavior during gastric disease. |
