| Primary Identifier | IPR029796 | Type | Family |
| Short Name | Metal_TF1 |
| description | Metal regulatory transcription factor 1 (MTF1) is a zinc-finger protein that activates transcription in response to heavy metals such as zinc, cadmium and copper, []and is also involved in the response to hypoxia []and oxidative stress []. It binds to metal response elements (MREs, also known as TGC box) associated with a number of metal- and stress-responsive genes [, ]. It is a key regulator of zinc in higher eukaryotes ranging from insects to mammals []. It also controls the expression of metallothioneins (MTs) and a number of other genes directly involved in the intracellular sequestration and transport of zinc []. |
