| First Author | Lezama-Dávila CM | Year | 1995 |
| Journal | In Vivo | Volume | 9 |
| Issue | 5 | Pages | 519-24 |
| PubMed ID | 8900933 | Mgi Jnum | J:40669 |
| Mgi Id | MGI:708030 | Citation | Lezama-Davila CM, et al. (1995) Vaccination of C57BL/6 mice against cutaneous leishmaniosis. Kinetics of antibody synthesis and induction of cellular responses. In Vivo 9(5):519-24 |
| abstractText | In this report, the effectiveness of vaccination of C57BL/6 mice and its association to long term production of IgG anti-Leishmania, delayed type hypersensitivity response (DTH) and the enlargement of the spleen associated to hyperplasia or parasite visceralization were studied. Mice were vaccinated with Leishmania-membrane antigens incorporated into liposomes, and two weeks later, animals received a homologous challenge with living amastigotes. Antibody levels were weekly recorded during 18 weeks after immunization. It was concluded that this vaccine induces disease-resistance in C57BL/6 mice and this effect correlates with the production of IgG anti-Leishmania, but not with the induction of a DTH or lymphoid hyperplasia. |
