First Author | Heldin CH | Year | 1997 |
Journal | Nature | Volume | 390 |
Issue | 6659 | Pages | 465-71 |
PubMed ID | 9393997 | Mgi Jnum | J:44762 |
Mgi Id | MGI:1101276 | Doi | 10.1038/37284 |
Citation | Heldin CH, et al. (1997) TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 390(6659):465-71 |
abstractText | The recent identification of the SMAD family of signal transducer proteins has unravelled the mechanisms by which transforming growth factor-beta (TGF-beta) signals from the cell membrane to the nucleus. Pathway-restricted SMADs are phosphorylated by specific cell-surface receptors that have serine/threonine kinase activity, then they oligomerize with the common mediator Smad4 and translocate to the nucleus where they direct transcription to effect the cell's response to TGF-beta. Inhibitory SMADs have been identified that block the activation of these pathway-restricted SMADs. |