| First Author | Li O | Year | 2004 |
| Journal | J Exp Med | Volume | 200 |
| Issue | 8 | Pages | 1083-9 |
| PubMed ID | 15477346 | Mgi Jnum | J:93953 |
| Mgi Id | MGI:3510302 | Doi | 10.1084/jem.20040779 |
| Citation | Li O, et al. (2004) CD24 expression on T cells is required for optimal T cell proliferation in lymphopenic host. J Exp Med 200(8):1083-9 |
| abstractText | It is well established that T lymphocytes undergo homeostatic proliferation in lymphopenic environment. The homeostatic proliferation requires recognition of the major histocompatibility complex on the host. Recent studies have demonstrated that costimulation-mediated CD28, 4-1BB, and CD40 is not required for T cell homeostatic proliferation. It has been suggested that homeostatic proliferation is costimulation independent. Here, we report that T cells from mice with a targeted mutation of CD24 have a remarkably reduced rate of proliferation when adoptively transferred into syngeneic lymphopenic hosts. The reduced proliferation cannot be attributed to abnormal survival and homing properties of the CD24-deficient T cells. T cell proliferation in allogeneic hosts is less affected by this mutation. These results demonstrate a novel function of CD24 expressed on T cells. Thus, although distinct costimulatory molecules are involved in antigen-driven proliferation and homeostatic proliferation, both processes can be modulated by costimulatory molecules. |
