| First Author | Li O | Year | 2006 |
| Journal | J Exp Med | Volume | 203 |
| Issue | 7 | Pages | 1713-20 |
| PubMed ID | 16769998 | Mgi Jnum | J:124399 |
| Mgi Id | MGI:3721471 | Doi | 10.1084/jem.20052293 |
| Citation | Li O, et al. (2006) Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts. J Exp Med 203(7):1713-20 |
| abstractText | In response to a lymphopenic cue, T lymphocytes undergo a slow-paced homeostatic proliferation in an attempt to restore T cell cellularity. The molecular interaction that maintains the pace of homeostatic proliferation is unknown. In this study, we report that in lymphopenic CD24-deficient mice, T cells launch a massive proliferation that results in the rapid death of the recipient mice. The dividing T cells have phenotypes similar to those activated by cognate antigens. The rapid homeostatic proliferation is caused by a lack of CD24 on dendritic cells (DCs). Interestingly, although CD24 expression in T cells is required for optimal homeostatic proliferation in the wild-type (WT) host, mice lacking CD24 on all cell types still mount higher homeostatic proliferation than the WT mice. Thus, a lack of CD24 in the non-T host cells bypassed the requirement for T cell expression of CD24 in homeostatic proliferation in the WT host. Our data demonstrate that CD24 expressed on the DCs limits T cell response to homeostatic cue and prevents fatal damage associated with uncontrolled homeostatic proliferation. |
