| First Author | Avivi-Arber L | Year | 2018 |
| Journal | PLoS One | Volume | 13 |
| Issue | 2 | Pages | e0191665 |
| PubMed ID | 29390019 | Mgi Jnum | J:257030 |
| Mgi Id | MGI:6116964 | Doi | 10.1371/journal.pone.0191665 |
| Citation | Avivi-Arber L, et al. (2018) Impaired bone healing at tooth extraction sites in CD24-deficient mice: A pilot study. PLoS One 13(2):e0191665 |
| abstractText | AIM: To use a micro-computed tomography (micro-CT) to quantify bone healing at maxillary first molar extraction sites, and test the hypothesis that bone healing is impaired in CD24-knockout mice as compared with wild-type C57BL/6J mice. MATERIALS AND METHODS: Under ketamine-xylazine general anaesthesia, mice had either extraction of the right maxillary first molar tooth or sham operation. Mice were sacrificed 1 (n = 12/group), 2 (n = 6/group) or 4 (n = 6/group) weeks postoperatively. The right maxillae was disected. Micro-CT was used to quantify differences in bone microstructural features at extrction sites, between CD24-knockout mice and wild-type mice. RESULTS: CD24-Knockout mice displayed impaired bone healing at extraction sites that was manifested as decreased trabecular bone density, and decreased number and thickness of trabeculae. CONCLUSIONS: This pilot study suggests that CD24 plays an important role in extraction socket bone healing and may be used as a novel biomarker of bone quality and potential therapeutic target to improve bone healing and density following alveolar bone injury. |
