| First Author | Zhou Q | Year | 1997 |
| Journal | Eur J Immunol | Volume | 27 |
| Issue | 10 | Pages | 2524-8 |
| PubMed ID | 9368605 | Mgi Jnum | J:125135 |
| Mgi Id | MGI:3757614 | Doi | 10.1002/eji.1830271009 |
| Citation | Zhou Q, et al. (1997) Homotypic interaction of the heat-stable antigen is not responsible for its co-stimulatory activity for T cell clonal expansion. Eur J Immunol 27(10):2524-8 |
| abstractText | The heat-stable antigen (HSA) is an important co-stimulatory molecule on antigen-presenting cells (APC). However, the receptor on T cells that receives the co-stimulatory signal from HSA has not been identified. Because the HSA is transiently expressed on T cells after the T cell receptor/CD3 complex is engaged, and because it can bind to itself in a homotypic fashion, it has been proposed that homotypic interaction of HSA is responsible for its co-stimulatory activity. Here we test this hypothesis using mice that have a targeted mutation of the HSA gene, as well as novel transgenic mice that constitutively express HSA on T cells. We show that HSA-deficient T cells remain responsive to co-stimulation by HSA. Furthermore, constitutive expression of HSA does not enhance T cell response to co-stimulatory by HSA. Taken together, our results demonstrate that homotypic interaction of HSA is not responsible for co-stimulation mediated by HSA expressed on APC. |
