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Protein Domain : RNA ligase domain, REL/Rln2

Primary Identifier  IPR021122 Type  Domain
Short Name  RNA_ligase_dom_REL/Rnl2
description  This entry represents the RNA ligase domain. RNA ligase enzyme repairs RNA strand breaks in nicked DNA:RNA and RNA:RNA but not in DNA:DNA duplexes []. Members of this RNA ligase family include:RNA editing ligase 1 (REL1), which is essential for RNA editing and may be active in U-deletion editing [, , ].RNA editing ligase 2 (REL2), which may be active in U-insertion editing [].RnlB RNA ligase 2 (or Rnl2), second RNA ligase of Enterobacteria phage T4 (Bacteriophage T4); unlike RNA ligase 1, RnlB prefers doule stranded substrates [, ].For the RNA-editing ligases Rel1 and Rel2 from Trypanosoma brucei brucei, Mg(2+) may play an important role both for nucleic acid binding and for activation of the nucleophile [].

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