| First Author | Matsumoto M | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 21 | Pages | 3805-12 |
| PubMed ID | 23022437 | Mgi Jnum | J:190309 |
| Mgi Id | MGI:5448583 | Doi | 10.1016/j.febslet.2012.09.018 |
| Citation | Matsumoto M, et al. (2012) SAP97 promotes the stability of Nax channels at the plasma membrane. FEBS Lett 586(21):3805-12 |
| abstractText | Na(x) is a sodium-level sensor for body fluids expressed in the circumventricular organs in the brain. Na(x) has a putative PSD-95/Disc-large/ZO-1 (PDZ)-binding motif at the carboxyl (C)-terminus. Here we found that several PDZ proteins bind to Na(x) by PDZ-array overlay assay. Among them, synapse-associated protein 97 (SAP97/DLG1) was coexpressed with Na(x) in the subfornical organ. In C6 glioblastoma cells, destruction of the PDZ-binding motif of Na(x) or depletion of SAP97 resulted in a decrease in cell-surface Na(x), which was attenuated with inhibitors of endocytosis. These results indicate that SAP97 contributes to the stabilization of Na(x) channels at the plasma membrane. |
