| First Author | Keszei M | Year | 2011 |
| Journal | J Exp Med | Volume | 208 |
| Issue | 4 | Pages | 811-22 |
| PubMed ID | 21422172 | Mgi Jnum | J:177322 |
| Mgi Id | MGI:5294736 | Doi | 10.1084/jem.20101653 |
| Citation | Keszei M, et al. (2011) A novel isoform of the Ly108 gene ameliorates murine lupus. J Exp Med 208(4):811-22 |
| abstractText | Studies of human systemic lupus erythematosus patients and of murine congenic mouse strains associate genes in a DNA segment on chromosome 1 with a genetic predisposition for this disease. The systematic analysis of lupus-prone congenic mouse strains suggests a role for two isoforms of the Ly108 receptor in the pathogenesis of the disease. In this study, we demonstrate that Ly108 is involved in the pathogenesis of lupus-related autoimmunity in mice. More importantly, we identified a third protein isoform, Ly108-H1, which is absent in two lupus-prone congenic animals. Introduction of an Ly108-H1-expressing transgene markedly diminishes T cell-dependent autoimmunity in congenic B6.Sle1b mice. Thus, an immune response-suppressing isoform of Ly108 can regulate the pathogenesis of lupus. |
