| First Author | Duprey P | Year | 1988 |
| Journal | Genes Dev | Volume | 2 |
| Issue | 12A | Pages | 1647-54 |
| PubMed ID | 2905686 | Mgi Jnum | J:9557 |
| Mgi Id | MGI:58017 | Doi | 10.1101/gad.2.12a.1647 |
| Citation | Duprey P, et al. (1988) A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine. Genes Dev 2(12A):1647-54 |
| abstractText | A mouse gene, Cdx-1, was isolated from an embryonic cDNA library using a Drosophila caudal gene probe. The deduced amino acid sequence of Cdx-1 contains conserved sequence domains along the entire gene, as well as a highly conserved caudal-type homeo box. A structural comparison suggests a common ancestral origin of mouse Cdx-1 and Drosophila caudal. The expression of Cdx-1 during embryogenesis was analyzed by Northern blotting and in situ hybridization. Cdx-1-specific transcripts are localized in the epithelial lining of the intestines beginning at 14 days' gestation. The expression of Cdx-1 in the intestine continues into adulthood, but cannot be detected in any other tissues. The Cdx-1 gene is the first homeo-box-containing gene expressed in cells derived from the embryonic endoderm. |
