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Protein Coding Gene : Hcfc1 host cell factor C1

Primary Identifier  MGI:105942 Organism  mouse, laboratory
Chromosome  X NCBI Gene Number  15161
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin DNA binding activity. Involved in release from viral latency. Acts upstream of or within blastocyst hatching. Located in cytoplasm and nucleus. Is expressed in early conceptus and secondary oocyte. Used to study methylmalonic acidemia and homocysteinemia cblX type. Human ortholog(s) of this gene implicated in methylmalonic acidemia and homocysteinemia cblX type. Orthologous to human HCFC1 (host cell factor C1).
PHENOTYPE: Conditional loss of the maternally inherited allele is embryonic lethal with increased apoptosis and reduced cell proliferation. Liver-specific knockout leads to decreased liver regeneration. [provided by MGI curators]
  • synonyms:
  • Hcfc1,
  • MGD-MRK-33621,
  • VP16 accessory protein,
  • host cell factor C1,
  • HCF-1,
  • HCF1,
  • expressed sequence AW060991,
  • AW060991,
  • MGI:2147992

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

10 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For