| First Author | AbuAttieh M | Year | 2007 |
| Journal | J Immunol | Volume | 178 |
| Issue | 5 | Pages | 2950-60 |
| PubMed ID | 17312140 | Mgi Jnum | J:144104 |
| Mgi Id | MGI:3830126 | Doi | 10.4049/jimmunol.178.5.2950 |
| Citation | AbuAttieh M, et al. (2007) Fitness of cell-mediated immunity independent of repertoire diversity. J Immunol 178(5):2950-60 |
| abstractText | Fitness of cell-mediated immunity is thought to depend on TCR diversity; however, this concept has not been tested formally. We tested the concept using JH(-/-) mice that lack B cells and have TCR Vbeta diversity <1% that of wild-type mice and quasimonoclonal (QM) mice with oligoclonal B cells and TCR Vbeta diversity 7% that of wild-type mice. Despite having a TCR repertoire contracted >99% and defective lymphoid organogenesis, JH(-/-) mice rejected H-Y-incompatible skin grafts as rapidly as wild-type mice. JH(-/-) mice exhibited T cell priming by peptide and delayed-type hypersensitivity, although these responses were less than normal owing either to TCR repertoire contraction or defective lymphoid organogenesis. QM mice with TCR diversity contracted >90%, and normal lymphoid organs rejected H-Y incompatible skin grafts as rapidly as wild type mice and exhibited normal T cell priming and normal delayed-type hypersensitivity reactions. QM mice also resisted Pneumocystis murina like wild-type mice. Thus, cell-mediated immunity can function normally despite contractions of TCR diversity >90% and possibly >99%. |
