Primary Identifier | MGI:4819807 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(APOE-DGAT2)29Far |
Strain of Origin | C57BL/6NHsd | Is Recombinase | false |
Is Wild Type | false |
description | It is not clear whether this is the same line called Liv-DGAT2-high in J:124005, as only two of five founder lines are analyzed therein and none are given line numbers. That line is said to have elevated expression of DGAT2 in the kidney and brain, as well as in the liver.(J:124005) |
molecularNote | This transgene contains promoter and enhancer sequences of the human apolipoprotein E gene driving expression of a 1.2 kb human acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) cDNA. Mice from founder line 29 exhibit overexpression of DGAT2 mRNA/protein specifically in the liver. |