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Allele : Tg(APOE-DGAT2)29Far transgene insertion 29, Bob Farese

Primary Identifier  MGI:4819807 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(APOE-DGAT2)29Far
Strain of Origin  C57BL/6NHsd Is Recombinase  false
Is Wild Type  false
description  It is not clear whether this is the same line called Liv-DGAT2-high in J:124005, as only two of five founder lines are analyzed therein and none are given line numbers. That line is said to have elevated expression of DGAT2 in the kidney and brain, as well as in the liver.(J:124005)
molecularNote  This transgene contains promoter and enhancer sequences of the human apolipoprotein E gene driving expression of a 1.2 kb human acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) cDNA. Mice from founder line 29 exhibit overexpression of DGAT2 mRNA/protein specifically in the liver.
  • mutations:
  • Insertion
  • synonyms:
  • Liv-DGAT2-high,
  • Liv-DGAT2-high
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

3 Publication categories

Trail: Allele