| First Author | Qi CF | Year | 2006 |
| Journal | Leuk Res | Volume | 30 |
| Issue | 2 | Pages | 153-63 |
| PubMed ID | 16122798 | Mgi Jnum | J:106754 |
| Mgi Id | MGI:3619479 | Doi | 10.1016/j.leukres.2005.06.025 |
| Citation | Qi CF, et al. (2006) Expression of the cyclin-dependent kinase inhibitor p27 and its deregulation in mouse B cell lymphomas. Leuk Res 30(2):153-63 |
| abstractText | CDKN1B (p27) regulates cell-cycle progression at the G1-S transition by suppressing the cyclin E/CDK2 kinase complex. In normal lymphocytes and most human B cell non-Hodgkin lymphomas (NHL), there is an inverse correlation between proliferative activity and expression of p27; however, a subset of NHL with high mitotic indices expresses p27, which is inactive due to sequestration in nuclear protein complexes or due to cytoplasmic retention. Our studies of mouse B cell NHL also identified cases with high proliferative activity and high levels of p27 at a surprisingly high frequency. Here, p27 was complexed with D-type cyclins 1 and 3 and with the COPS9 protein, JAB1. In addition, we found cytoplasmic sequestration following phosphorylation by activated AKT. |
