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Allele : Prnp<tm1Lnq> prion protein; targeted mutation 1, Susan Lindquist
Primary Identifier  MGI:4412098 Allele Type  Targeted
Gene  Prnp Transmission  Germline
Strain of Origin  129P2/OlaHsd Is Recombinase  false
Is Wild Type  false
molecularNote  The third exon was replaced with an HPRT mini gene that was then replaced with a representative sequence containing two amino acid substitutions found in the human sequence (L108M and V111M). These substitutions allow for transmission barrier against mouse scrapies and immunoreactivity to the 3F4 antibody.
  • mutations:
  • Insertion
  • synonyms:
  • PrP<3F4WT>,
  • PrP<3F4WT>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

5 Publication categories





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