| First Author | Lewin HA | Year | 1994 |
| Journal | Anim Genet | Volume | 25 Suppl 1 |
| Pages | 13-8 | PubMed ID | 7943979 |
| Mgi Jnum | J:20195 | Mgi Id | MGI:68304 |
| Doi | 10.1111/j.1365-2052.1994.tb00398.x | Citation | Lewin HA, et al. (1994) The bovine B and C blood group systems are not likely to be the orthologues of human RH: an interesting twist in the comparative map. Anim Genet 25 Suppl 1:13-8 |
| abstractText | We tested the hypothesis that either the bovine B or C blood group system is the orthologue of human RH. A comparative linkage mapping strategy was applied, using blood typing and restriction fragment length polymorphism (RFLP) analysis of four loci linked to RH on HSA1; PGD, FGR, ALPL and FUCA1. Four sires with a total of 255 half-sib offspring were used for the linkage analysis. Strong support for linkage between ALPL, FUCA1 and FGR was obtained for all sire families (lod scores > 11 for all pairwise comparisons). This new linkage group was assigned to bovine synteny group U17 based on previous somatic cell mapping of the FGR locus. The most favoured order is ALPL-FUCA1-FGR (2.18:1), with ALPL and FGR 5.4 CM and 6.3 CM, respectively, from FUCA1. The B and C blood group systems and PGD were genetically independent of each other and all other markers, indicating that neither B nor C is likely to be the bovine orthologue of human RH. However, given available comparative mapping data, there is some chance that the bovine orthologue of RH is on bovine synteny group U6. Although gene order appears to be conserved with humans, the differences in recombination rates between these three loci in cattle, humans and mice strongly suggest that it is not possible to use human map distances to predict map distances in cattle, making it imperative that bovine gene mappers continue to emphasize adding type I markers to the bovine linkage map. |
