Primary Identifier | MGI:1919257 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 72007 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within several processes, including negative regulation of osteoblast differentiation; substrate adhesion-dependent cell spreading; and type II pneumocyte differentiation. Located in endoplasmic reticulum. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and respiratory system. Orthologous to human FNDC3B (fibronectin type III domain containing 3B). PHENOTYPE: Mice homozygous for a knock-out allele die shortly after birth despite normal energy homeostasis. Mouse embryonic fibroblasts homozygous for a knock-out allele exhibit impaired adipogenesis and enhanced osteogenesis. [provided by MGI curators] |