| First Author | Tominaga K | Year | 2004 |
| Journal | FEBS Lett | Volume | 577 |
| Issue | 1-2 | Pages | 49-54 |
| PubMed ID | 15527760 | Mgi Jnum | J:94268 |
| Mgi Id | MGI:3511725 | Doi | 10.1016/j.febslet.2004.09.062 |
| Citation | Tominaga K, et al. (2004) The novel gene fad104, containing a fibronectin type III domain, has a significant role in adipogenesis. FEBS Lett 577(1-2):49-54 |
| abstractText | A novel gene named fad104 (factor for adipocyte differentiation-104), whose expression level quickly increased in the early stage of adipogenesis, was isolated and characterized. The deduced amino acid sequence of fad104 revealed the possible presence of a fibronectin type III domain and transmembrane domain. The expression of fad104 was detected in adipocyte differentiable 3T3-L1 cells but not observed in the non-adipogenic cell line NIH-3T3. Moreover, the ability of 3T3-L1 cells to differentiate declined with the knockdown of fad104 by RNA interference, strongly indicating that fad104 functions as a positive regulator of adipogenesis. |
