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Protein Coding Gene : Itga3 integrin alpha 3

Primary Identifier  MGI:96602 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  16400
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable several functions, including fibronectin binding activity; integrin binding activity; and protein heterodimerization activity. Involved in postsynapse organization and synaptic membrane adhesion. Acts upstream of or within several processes, including dendritic spine maintenance; exploration behavior; and negative regulation of Rho protein signal transduction. Located in several cellular components, including basolateral plasma membrane; external side of plasma membrane; and synaptic membrane. Is active in glutamatergic synapse; neuromuscular junction; and presynaptic active zone membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa. Orthologous to human ITGA3 (integrin subunit alpha 3).
PHENOTYPE: Homozygotes for a targeted null mutation exhibit defects of the kidney and submandibular gland, decreased bronchial branching of the lungs, skin blisters at the dermal-epidermal junction, abnormal layering of the cerebral cortex and perinatal lethality. [provided by MGI curators]
  • synonyms:
  • VLA-3 alpha 3,
  • integrin alpha 3,
  • MGI:2143964,
  • AA407068,
  • alpha3-integrin,
  • MGD-MRK-11481,
  • expressed sequence AA407068,
  • Itga3

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

11 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For