| Primary Identifier | MGI:3053950 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(SOD1)10Cje |
| Strain of Origin | (C57BL/6J x SJL/J)F1 | Is Recombinase | false |
| Is Wild Type | false |
| description | Line 3 was also produced. Transgenic mice on a C57BL/6 background are viable. Although homozygote males are sterile, homozygote females are fertile. Transgenic mice express three times the normal level of SOD1 in the blood, brain, and fibroblasts. |
| molecularNote | The entire human SOD1 sequence was used for the transgene. Eight copies of the transgene inserted into Chromosome 10 (J:18645). Northern blot analysis of brain and liver from transgenic animals showed expression of 0.9 kb and 0.7 kb transcripts similar to that in humans. Transgenic animals exhibited increased enzyme activity in nearly all tissues examined. |
