| First Author | Cheyette BN | Year | 2002 |
| Journal | Dev Cell | Volume | 2 |
| Issue | 4 | Pages | 449-61 |
| PubMed ID | 11970895 | Mgi Jnum | J:80949 |
| Mgi Id | MGI:2447631 | Doi | 10.1016/s1534-5807(02)00140-5 |
| Citation | Cheyette BN, et al. (2002) Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. Dev Cell 2(4):449-61 |
| abstractText | Dapper was isolated in a screen for proteins interacting with Dishevelled, a key factor in Wnt signaling. Dapper and Dishevelled colocalize intracellularly and form a complex with Axin, GSK-3, CKI, and beta-catenin. Overexpression of Dapper increases Axin and GSK-3 in this complex, resulting in decreased soluble beta-catenin and decreased activation of beta-catenin-responsive genes. Dapper also inhibits activation by Dishevelled of c-Jun N-terminal kinase (JNK), a component of beta-catenin-independent Frizzled signaling. Inhibition of Dapper activates both beta-catenin-responsive genes and an AP1-responsive promoter, demonstrating that Dapper is a general Dishevelled antagonist. Depletion of maternal Dapper RNA from Xenopus embryos results in loss of notochord and head structures, demonstrating that Dapper is required for normal vertebrate development. |
