Primary Identifier | MGI:6144040 | Allele Type | Targeted |
Attribute String | Modified isoform(s) | Gene | Chd8 |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A pair of loxP sites with a loxP-flanked neo gene cassette flanking alternatively spliced exons 11 to 13 was generated. Transient Cre expression in ES cells resulted in the deletion of exons 11-13 and the lack of expression of the long isoform of the Chd8 gene. The short isoform is expressed. |