| First Author | Cavelli ML | Year | 2023 |
| Journal | iScience | Volume | 26 |
| Issue | 3 | Pages | 106186 |
| PubMed ID | 36895652 | Mgi Jnum | J:351817 |
| Mgi Id | MGI:7443796 | Doi | 10.1016/j.isci.2023.106186 |
| Citation | Cavelli ML, et al. (2023) Sleep/wake changes in perturbational complexity in rats and mice. iScience 26(3):106186 |
| abstractText | In humans, the level of consciousness is assessed by quantifying the spatiotemporal complexity of cortical responses using Perturbational Complexity Index (PCI) and related PCI(st) (st, state transitions). Here we validate PCI(st) in freely moving rats and mice by showing that it is lower in NREM sleep and slow wave anesthesia than in wake or REM sleep, as in humans. We then show that (1) low PCI(st) is associated with the occurrence of an OFF period of neuronal silence; (2) stimulation of deep, but not superficial, cortical layers leads to reliable PCI(st) changes across sleep/wake and anesthesia; (3) consistent PCI(st) changes are independent of which single area is being stimulated or recorded, except for recordings in mouse prefrontal cortex. These experiments show that PCI(st) can reliably measure vigilance states in unresponsive animals and support the hypothesis that it is low when an OFF period disrupts causal interactions in cortical networks. |
