| First Author | Vosshenrich CA | Year | 2003 |
| Journal | Nat Immunol | Volume | 4 |
| Issue | 8 | Pages | 773-9 |
| PubMed ID | 12872121 | Mgi Jnum | J:84670 |
| Mgi Id | MGI:2668809 | Doi | 10.1038/ni956 |
| Citation | Vosshenrich CA, et al. (2003) Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development. Nat Immunol 4(8):773-9 |
| abstractText | Deletions of interleukin 7 (IL-7) or its receptor components permit fetal but not adult B cell development in mice. Mice deficient in IL-7 receptor alpha (IL-7R alpha) had 1% the number of B cells of controls and 10% that of mice deficient in the common gamma chain. As IL-7R alpha is also a receptor for thymic stromal-derived lymphopoietin (TSLP), we assayed the ability of TSLP to support proliferation of fetal or adult precursor B cells. Only fetal-derived pro-B cells were able to respond to TSLP, although pre-B cells from both origins were TSLP-responsive. Fetal but not adult precursors generated a measurable B cell compartment in the absence of IL-7. The residual B cells found in IL-7R alpha-deficient mice required fetal liver kinase 2 (Flk-2) for their development. Thus, IL-7R alpha- and Flk-2-mediated signals account for the generation of almost all mouse B lymphocytes. |
