| First Author | Dudda JC | Year | 2008 |
| Journal | J Exp Med | Volume | 205 |
| Issue | 7 | Pages | 1559-65 |
| PubMed ID | 18573908 | Mgi Jnum | J:137389 |
| Mgi Id | MGI:3799419 | Doi | 10.1084/jem.20072594 |
| Citation | Dudda JC, et al. (2008) Foxp3+ regulatory T cells maintain immune homeostasis in the skin. J Exp Med 205(7):1559-65 |
| abstractText | Cutaneous immune responses must be tightly controlled to prevent unwanted inflammation in response to innocuous antigens, while maintaining the ability to combat skin-tropic pathogens. Foxp3(+) regulatory T (T reg) cells are potent immune regulators and are found at high frequency in both human and mouse skin. Although T reg cells migrate to the skin and can dampen immune responses during experimentally induced inflammation or infection, the importance of cutaneous T reg cells for maintaining normal immune homeostasis in the skin has not been addressed. To selectively block T reg cell function in the skin, we restored the T reg cell compartment in Foxp3-deficient scurfy mice with cells whose ability to migrate to the skin was impaired because of targeted mutation of alpha-1,3-fucosyltransferase VII (Fut7). Although Fut7-deficient T reg cells were present at normal frequency and could function in all other tissues examined, these animals rapidly developed severe cutaneous inflammation. Thus, skin-resident T reg cell are essential for maintaining normal immune homeostasis at this site. |
