|  Help  |  About  |  Contact Us

Protein Domain : Cadherin-23

Primary Identifier  IPR033030 Type  Family
Short Name  CDH23
description  Cadherin-23 (CDH23) is an adhesion protein that contains several calcium dependent extracellular (EC) domains. It is required for establishing and/or maintaining the proper organisation of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development []. CDH23 is part of the tip-links, oblique filaments that interconnect the stereocilia of the hair bundle []. CDH23 is associated with Usher syndrome type 1 (USH1D), isolated deafness (DFNB12) in humans, and deafness and circling behavior in waltzer mice [, ].

0 Child Features

0 Parent Features

17 Protein Domain Regions