Primary Identifier | MGI:1914853 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 67603 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables phosphoprotein phosphatase activity. Acts upstream of or within negative regulation of protein phosphorylation and regulation of heart growth. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; renal cortex; and sensory organ. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to human DUSP6 (dual specificity phosphatase 6). PHENOTYPE: Mice homozygous or heterozygous for a null mutation display partial penetrance of postnatal lethality, reduced body weight, and abnormal growth plate morphology. [provided by MGI curators] |