| First Author | Galan-Caridad JM | Year | 2007 |
| Journal | Cell | Volume | 129 |
| Issue | 2 | Pages | 345-57 |
| PubMed ID | 17448993 | Mgi Jnum | J:149654 |
| Mgi Id | MGI:3848797 | Doi | 10.1016/j.cell.2007.03.014 |
| Citation | Galan-Caridad JM, et al. (2007) Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell 129(2):345-57 |
| abstractText | Stem cells (SC) exhibit a unique capacity for self-renewal in an undifferentiated state. It is unclear whether the self-renewal of pluripotent embryonic SC (ESC) and of tissue-specific adult SC such as hematopoietic SC (HSC) is controlled by common mechanisms. The deletion of transcription factor Zfx impaired the self-renewal but not the differentiation capacity of murine ESC; conversely, Zfx overexpression facilitated ESC self-renewal by opposing differentiation. Furthermore, Zfx deletion abolished the maintenance of adult HSC but did not affect erythromyeloid progenitors or fetal HSC. Zfx-deficient ESC and HSC showed increased apoptosis and SC-specific upregulation of stress-inducible genes. Zfx directly activated common target genes in ESC and HSC, as well as ESC-specific target genes including ESC self-renewal regulators Tbx3 and Tcl1. These studies identify Zfx as a shared transcriptional regulator of ESC and HSC, suggesting a common genetic basis of self-renewal in embryonic and adult SC. |
