| Primary Identifier | MGI:2387893 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Tpm1 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The striated muscle-specific exons 12 and 13 were replaced with an HPRT cassette in the reverse orientation. While the targeting construct was designed to knock-out the striated muscle isoform, the targeted allele is null. Interestingly, heterozygotes exhibit normal protein levels, despite a ~50% reduction in mRNA levels and absence of compensation by the striated muscle beta or the slow skeletal alpha isoforms, suggesting that a compensatory mechanism may operate at the translational level. |
