Primary Identifier | MGI:5485027 | Allele Type | Transgenic |
Attribute String | Null/knockout, Recombinase | Gene | E2f1 |
Strain of Origin | C57BL/6 x C3H | Is Recombinase | true |
Is Wild Type | false |
molecularNote | A transgenic insert containing cre recombinase, under the control of the 1.3 kb 5' promoter and 5.5 kb 3' enhancer of the mouse Wnt1, wingless-related MMTV integration site 1 was injected into fertilized B6C3 hybrid mouse eggs. Founder line 2 inserted into the gene at 154561346-154561603 (Build GRCm38/mm10) resulting in a 257 bp deletion and a 45 Kb inverted segment in exon 5 of the gene. The inversion contains all of exon 5, but deletes 23 Kb including exons 6 and 7. Founder line 2 has a copy number of 1-3. |