| Primary Identifier | IPR034935 | Type | Family |
| Short Name | FCHSD1 |
| description | F-BAR proteins been identified as important coordinators for membrane curvatures, which regulate cellular processes such as endocytosis, phagocytosis, adhesion and migration []. They bind to cell membrane via a N-terminal F-BAR domain, which associates with membrane phospholipids []. FCHSD1 and FCHSD2 are homologous proteins containing an amino-terminal F-BAR domain and two SH3 domains near their carboxyl-termini. FCHSD1 is expressed in cochlear sensory hair cells, and has been shown to bind via its F-BAR domain to the SH3 domain of Sorting Nexin 9, a BAR protein that has been shown to promote WASP-Arp2/3-dependent F-actin polymerization []. |
