| First Author | Cai J | Year | 2023 |
| Journal | Cell Rep | Volume | 42 |
| Issue | 7 | Pages | 112789 |
| PubMed ID | 37422762 | Mgi Jnum | J:339326 |
| Mgi Id | MGI:7518133 | Doi | 10.1016/j.celrep.2023.112789 |
| Citation | Cai J, et al. (2023) AgRP neurons are not indispensable for body weight maintenance in adult mice. Cell Rep 42(7):112789 |
| abstractText | In addition to their role in promoting feeding and obesity development, hypothalamic arcuate agouti-related protein/neuropeptide Y (AgRP/NPY) neurons are widely perceived to be indispensable for maintaining normal feeding and body weight in adults, and consistently, acute inhibition of AgRP neurons is known to reduce short-term food intake. Here, we adopted complementary methods to achieve nearly complete ablation of arcuate AgRP/NPY neurons in adult mice and report that lesioning arcuate AgRP/NPY neurons in adult mice causes no apparent alterations in ad libitum feeding or body weight. Consistent with previous studies, loss of AgRP/NPY neurons blunts fasting refeeding. Thus, our studies show that AgRP/NPY neurons are not required for maintaining ad libitum feeding or body weight homeostasis in adult mice. |
