| Primary Identifier | MGI:1345275 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 18173 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables iron ion transmembrane transporter activity; manganese ion transmembrane transporter activity; and metal cation:proton antiporter activity. Involved in iron ion transport and manganese ion transport. Acts upstream of or within several processes, including defense response to other organism; intracellular monoatomic cation homeostasis; and regulation of gene expression. Located in late endosome membrane; lysosomal membrane; and phagocytic vesicle membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including Buruli ulcer disease; autoimmune disease (multiple); inflammatory bowel disease (multiple); leishmaniasis (multiple); and tuberculosis (multiple). Orthologous to human SLC11A1 (solute carrier family 11 member 1). PHENOTYPE: Mutations in this gene are associated with susceptibility to infection with pathogens, including Myobacterium, Salmonella and Leishmania. Depending on the mutation, mutants may exhibit either increased or decreased susceptibility to infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
