| Type | MGI:General | Description | aging mice develop lymphocytic infiltrates in the stroma early stage changes include mild and focal lymphocyte infiltrations with occasional plasma cells, around centrilobular thin walled vessels middle phase changes include thick and continuous infiltrates expanding around vessels and bronchioli and expanding into inter-alveolar compartment late stage changes include substantial accumulation of immunoglobulin producing plasma cells with Russell bodies, filling of alveoli with macrophage, necrotizing pseudogranulomatous nodules advanced lesions in 15% of mice by 6-12 months and in 48% by 12-24 months |
