| First Author | De Sarro GB | Year | 1989 |
| Journal | Neuropharmacology | Volume | 28 |
| Issue | 3 | Pages | 211-5 |
| PubMed ID | 2566944 | Mgi Jnum | J:25998 |
| Mgi Id | MGI:73832 | Doi | 10.1016/0028-3908(89)90095-6 |
| Citation | De Sarro GB, et al. (1989) Antagonists of adenosine and alpha-2-adrenoceptors reverse the anticonvulsant effects of tizanidine in DBA/2 mice. Neuropharmacology 28(3):211-5 |
| abstractText | The anticonvulsant activity of 5-chloro-4-(2-imidazolin-2yl-amino)-2,1,3-benzothiazole, tizanidine, was studied following intraperitoneal (i.p.) administration in DBA/2 mice (which show sound-induced seizures). Protection against sound-induced seizures was observed after tizanidine, (0.5-4 mg/kg i.p.). The ED50 values for suppression of the tonic, clonic and wild running phases of sound-induced seizures were 0.54, 0.76 and 1.43 mg/kg, respectively. This protective action was significantly reduced by pretreatment with aminophylline (25 mg/kg i.p.), yohimbine (1 mg/kg i.p.) or piperoxan (20 mg/kg i.p.). Methysergide, a serotonin antagonists, did not significantly reduce the anticonvulsant effects of tizanidine. The present experiments suggest an involvement of purinergic and adrenergic mechanisms in the anticonvulsant action of tizanidine. |
