| Primary Identifier | MGI:6258653 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Vwf |
| Transmission | Germline | Strain of Origin | C57BL/6 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 28 was replaced with one in which a single base pair modification (CTG to ATG) resulted in a valine to methionine substitution at amino acid 1316 (V1316M). A neomycin selection cassette flanked by loxP sites was inserted upstream of exon 28. This mutation is found in von Willebrand's disease type 2B patients. Cre-mediated recombination removed the neomycin cassette. |
