| First Author | Mizota A | Year | 2002 |
| Journal | Invest Ophthalmol Vis Sci | Volume | 43 |
| Issue | 12 | Pages | 3754-7 |
| PubMed ID | 12454047 | Mgi Jnum | J:80601 |
| Mgi Id | MGI:2446397 | Citation | Mizota A, et al. (2002) Effect of body temperature on electroretinogram of mice. Invest Ophthalmol Vis Sci 43(12):3754-7 |
| abstractText | PURPOSE: To investigate the ERG alterations induced by changes in body temperature in mice. METHODS: Three-week-old BALB/c mice were used. Rectal temperature was measured with a digital thermometer and taken as the body temperature. In experiment 1, the body temperature was kept at 33 degrees C, and the ERGs elicited by a constant stimulus intensity were recorded every 5 minutes. In experiment 2, the body temperature was lowered in five steps from 38 degrees C to 33 degrees C, 28 degrees C, 23 degrees C, and 18 degrees C. At each body temperature, ERGs elicited by different stimulus intensities were recorded. RESULTS: In experiment 1, the mean amplitudes and implicit times of both the a- and b-waves did not change significantly. In experiment 2, the amplitude of both the a- and b-waves decreased significantly with a decrease in body temperature, and the implicit times of the a- and b-waves were prolonged with a decrease in body temperature. CONCLUSIONS: Body temperature greatly affects the amplitude and timing of the ERG. Great care must be taken to maintain as normal a body temperature as possible when using the ERG to evaluate the retina, especially in small animals such as mice. |
