| Primary Identifier | IPR038401 | Type | Homologous_superfamily |
| Short Name | Rev1_C_sf |
| description | This entry represents the C-terminal domain of DNA repair protein Rev1, an enzyme which allows DNA synthesis to proceed even in the presence of DNA damage. Rev1 belongs to the Y-family of TLS polymerases. Rev1 possess a limited catalytic activity but it has a second and more important function which involved the recruitment and coordination of other Y-family TLS polymerases and the regulatory subunit Rev7 of the B-family polymerase pol. This interaction is mediated by its C-terminal domain which therefore serves as a scaffold that allows access of the Y-family polymerases to their cognate DNA lesions and the subsequent exchange to pol, which then extends the distorted DNA primer terminus opposite the lesion [, ]. This domain adopts a four-helix bundle that interacts with Rev7, Polkappa and Poleta. However, the Rev7-binding interface is distinct from the binding site of DNA polymerase eta or kappa [, ]. |
