| Primary Identifier | MGI:96247 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 15516 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables protein folding chaperone; protein kinase binding activity; and tau protein binding activity. Contributes to protein kinase regulator activity. Involved in several processes, including cellular response to heat; negative regulation of proteasomal protein catabolic process; and protein folding. Acts upstream of or within cellular response to interleukin-4; negative regulation of apoptotic process; and placenta development. Located in growth cone; neuronal cell body; and perinuclear region of cytoplasm. Part of HSP90-CDC37 chaperone complex. Is expressed in several structures, including branchial arch; central nervous system; eye; jaw; and limb. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to several human genes including HSP90AB1 (heat shock protein 90 alpha family class B member 1). PHENOTYPE: Homozygotes for a gene-trapped null mutation exhibit placental defects including failure to form a placental labyrinth and lack of expansion of allantoic blood vessels. Mutants die around mid-gestation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
