| First Author | Mountz JD | Year | 1984 |
| Journal | Science | Volume | 226 |
| Issue | 4678 | Pages | 1087-9 |
| PubMed ID | 6494925 | Mgi Jnum | J:7637 |
| Mgi Id | MGI:56106 | Doi | 10.1126/science.6494925 |
| Citation | Mountz JD, et al. (1984) Autoimmunity and increased c-myb transcription. Science 226(4678):1087-9 |
| abstractText | A single recessive gene, lpr, induces an autoimmune-lymphoproliferative syndrome in several strains of mice. The lymphoid organs of lpr/lpr mice contained cells with increased amounts of myb RNA, which codes for a protein found in the nucleus. A similar human lymphoproliferative disorder also had an increase in c-myb expression. Mouse T cells induced by mitogens to proliferate did not express large amounts of myb RNA, indicating that marked myb expression is not a general feature of lymphocyte activation and proliferation. |
