| Primary Identifier | MGI:104908 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 19229 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; regulation of cell migration; and regulation of organelle organization. Acts upstream of with a positive effect on positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within cellular response to fluid shear stress and protein phosphorylation. Located in nucleus and perinuclear region of cytoplasm. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynapse. Is expressed in several structures, including blastocyst; early embryo; gonad; gonad primordium; and liver. Human ortholog(s) of this gene implicated in breast cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta). PHENOTYPE: Mice homozygous for a knock-out allele show alterations in endothelial nitric oxide synthase-mediated vascular function and angiogenic responses. Mice homozygous for a second knock-out allele exhibit multiple defects in macrophage migration and function. Homozygous KO also results in increased female fecundity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
