Primary Identifier | MGI:2386295 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Scgb1a1 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A portion of exon 2 and all of exon 3 were replaced with a neomycin selection cassette. Transcript was undetected by RT-PCR analysis of total lung RNA obtained from homozygous mutant mice. The absence of protein was verified by Western blot analysis of lung lysates and immunohistochemical analysis of bronchiolar epithelial cells. Analysis of prostate and uterine tissue obtained from homozygous mutant mice yielded corroborative results. |