| Primary Identifier | MGI:2180721 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Aldh1a2 |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exons 3 and 4 are deleted and are replaced by a PGK-hygromycin selectable marker. This prevents translation beyond residue 67 and deletes the entire catalytic domain (residues 271-484) including the catalytic cysteine at residue 301. Whole mount immunohistochemistry experiments confirmed that the encoded protein was undetectable in homozygous embryos. |
