| Primary Identifier | MGI:1928478 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 56710 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in cellular response to retinoic acid; central nervous system development; and negative regulation of mitotic cell cycle. Acts upstream of or within several processes, including behavioral fear response; maternal behavior; and protein stabilization. Is active in glutamatergic synapse. Is expressed in central nervous system; dorsal root ganglion; submandibular gland primordium; and urogenital sinus. Used to study attention deficit hyperactivity disorder and autism spectrum disorder. Orthologous to human BRINP1 (BMP/retinoic acid inducible neural specific 1). PHENOTYPE: Homozygous null mice show increased adult neurogenesis in the subgranular zone of the dentate gyrus, altered neuronal differentiation in the hippocampus, and behavioral anomalies such as hyperactivity, reduced anxiety-like behaviors, poor social interaction, and a slight deficit in working memory. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
