| First Author | Belandia B | Year | 2000 |
| Journal | J Biol Chem | Volume | 275 |
| Issue | 40 | Pages | 30801-5 |
| PubMed ID | 10934189 | Mgi Jnum | J:65012 |
| Mgi Id | MGI:1891576 | Doi | 10.1074/jbc.C000484200 |
| Citation | Belandia B, et al. (2000) Functional interaction between the p160 coactivator proteins and the transcriptional enhancer factor family of transcription factors. J Biol Chem 275(40):30801-5 |
| abstractText | SRC1, initially identified as a nuclear receptor coactivator, was found to interact with a member of the transcriptional enhancer factor (TEF) family of transcription factors, TEF-4. The interaction, which occurs in both intact cells and in a cell-free system, is mediated by the highly conserved basic helix-loop-helix/Per-Arnt-Sim (bHLH-PAS) domain present in the N-terminal region of SRC1. Moreover, all three members of the p160 family of nuclear receptor coactivators, SRC1, TIF2, and RAC3, are able to potentiate transcription from a TEF response element in transient transfection experiments, and this activation requires the presence of the bHLH-PAS domain. These results suggest that the p160 proteins could be bona fide coactivators of the TEF family of transcription factors. |
