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HT Experiment :

Experiment Id  GSE138153 Name  Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice
Experiment Type  RNA-Seq Study Type  WT vs. Mutant
Source  GEO Curation Date  2023-11-28
description  Epigenetic regulation of gene expression through histone modifications like methylation of various lysine residues are essential for embryonic development. Here we removed SETD2, a methyltransferase for histone 3 lysine 36 trimethylation (H3K36me3), in the developing dorsal forebrain in mice and show it is required for proper area patterning (arealization) of the neocortex and the formation of thalamo-cortico-thalamic circuits by maintaining the expression of clustered protocadherin (Pcdh) genes in an H3K36me3 methyltransferase-dependent manner. Moreover, the Setd2 mutant mice exhibit defects in social interaction, motor endurance and spatial memory, reminiscent of patients with the Sotos-like syndrome bearing SETD2 mutations. Cortex mRNA profiles of E13.5 control and Emx1-Cre;Setd2 fl/fl mice were generated by deep sequencing, in triplicate, using Illumina NovaSeq 6000.
  • variables:
  • bulk RNA-seq,
  • genotype

1 Publications

Trail: HTExperiment

6 Samples

Trail: HTExperiment