| First Author | Carretón O | Year | 2012 |
| Journal | Exp Neurol | Volume | 237 |
| Issue | 2 | Pages | 335-45 |
| PubMed ID | 22776425 | Mgi Jnum | J:192395 |
| Mgi Id | MGI:5465039 | Doi | 10.1016/j.expneurol.2012.06.033 |
| Citation | Carreton O, et al. (2012) Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels. Exp Neurol 237(2):335-45 |
| abstractText | Brain-derived neurotrophic factor (BDNF) is a key player in learning and memory processes. However, little is known about brain area-specific functions of this neurotrophin. Here we investigated whether BDNF could differently affect motor neocortical and hippocampal-related cognitive and plastic morphologic changes in young (12-week-old) and middle-aged (30-week-old) BDNF heterozygous (BDNF(+)/(-)) and wild type (wt) mice. We found that at 30 weeks of age, BDNF(+)/(-) mice showed impaired performance in accelerating rotarod and grasping tests while preserved spatial learning in a T-maze and recognition memory in an object recognition task compared with wt mice suggesting a specific neocortical dysfunction. Accordingly, a significant reduction of synaptic markers (PSD-95 and GluR1) and corresponding puncta was observed in motor neocortex but not in hippocampus of BDNF(+)/(-) mice. Interestingly, 30-week-old BDNF(+)/(-) mice displayed increased TrkB levels in the hippocampus but not in the motor neocortex, which suggests specific hippocampal compensatory mechanisms as a consequence of BDNF decrease. In conclusion, our data indicates that BDNF could differentially regulate the neuronal micro-structures and cognition in a region-specific and in an age-dependent manner. |
